The role and differences between high substitution hydroxypropyl cellulose and low substitution hydroxypropyl cellulose.

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Industry News

Release time:

2019-06-18

Hydroxypropyl cellulose can be divided into low substituted hydroxypropyl cellulose (L-HPC) and high substituted hydroxypropyl cellulose (H-HPC).
 
Characteristics of highly substituted hydroxypropyl cellulose:
 
1. Soluble in water and various organic solvents at room temperature. For example: anhydrous methanol, ethanol, isopropanol, propylene glycol, dichloromethane, and also soluble in acetone, chloroform, toluene, and solvent agents, the solution is transparent.
 
2. H-HPC is a good thermoplastic material with excellent film-forming properties, very tough film-forming ability, good gloss, and sufficient elasticity. The ash content is extremely low, which gives the product excellent adhesion. It is very stable as an emulsion thickener and has good dispersibility.
 
3. H-HPC itself has no pharmacological effect, is non-toxic, and is harmless to physiology.
 
4. H-HPC is chemically inert and difficult to react chemically with other substances.
 
5. The distribution of substituents is relatively uniform and sufficient, and H-HPC has strong antibacterial properties.
 
6. Low balanced moisture content.
 
7. Because it is non-ionic, it does not gel in acidic solutions and exhibits excellent stability across various pH values.
 
8. The concentrated solution of H-HPC can form normally oriented liquid crystals.
 
9. H-HPC aqueous solution has surfactant properties.
 
10. The aqueous solution undergoes reversible gelation and dissolution processes with increasing and decreasing temperature.
 
Characteristics of low substituted hydroxypropyl cellulose:
 
1. Properties: Dissolving low substituted hydroxypropyl cellulose in water forms a clear or slightly turbid colloidal solution; it is insoluble in ethanol, acetone, or ether. 2. Compatibility changes: Low substituted hydroxypropyl cellulose cannot be compatible with other high concentration electrolytes, or it may cause "salting out". The dissolved low substituted hydroxypropyl cellulose has certain contraindications with phenolic derivatives such as methyl and para-hydroxybenzoate propyl esters.
 
Low substituted hydroxypropyl cellulose (L-HPC) is mainly used as a disintegrant and binder for tablets. Low substituted hydroxypropyl cellulose (L-HPC) is characterized as a binder and disintegrant that is easy to compress. It has strong applicability, especially suitable for difficult-to-form, plastic, and brittle films. Adding low substituted hydroxypropyl cellulose (L-HPC) can improve the hardness and appearance of tablets, and also allows for rapid disintegration of tablets. Even when the hardness of the film reaches 13kg, disintegration only takes ten minutes to improve the intrinsic quality of the film and enhance efficacy; the long-term storage disintegration degree of tablets made with low substituted hydroxypropyl cellulose (L-HPC) is not affected.
 
For tablet binders, it is usually added at 5-20% during wet granulation, and 5-20% when directly compressing powder, used as a tablet disintegrant at a dosage of 2-10%, generally 5%, added depending on the specific formulation.
 
Low substituted hydroxypropyl cellulose (L-HPC) can also be used as a food additive in the food industry, as an emulsifier, stabilizer, suspending agent, thickener, and film-forming agent for beverages, cakes, jams, etc.
 
Low substituted hydroxypropyl cellulose (L-HPC) is also used in the chemical industry for the manufacture of cosmetics, such as creams, shampoos, and lotions.

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